Attention Deficit Hyperactivity Disorder (ADHD) is widely misunderstood. Its name implies that it’s a disorder when, in fact, it’s more accurate to understand it as a neurodevelopmental condition. It’s a natural variation in brain wiring that affects attention, self-regulation, and executive function. Recognising it as part of neurodiversity helps reduce stigma and shift the focus from deficits to differences. We don’t all think in the same way, nor should we.

While ADHD has traditionally been linked to dopamine dysregulation, the idea of a simple "dopamine deficit" is, quite frankly, overly reductive. The current research highlights a complex interplay of genetics, neurobiology, and environmental factors that contribute to ADHD characteristics.

Your body has several detoxification systems working tirelessly behind the scenes to keep you healthy: the liver, kidneys, gut, and skin. These systems filter out toxins, process waste, and help your body maintain balance. But what many don’t realise is that the nervous system—and particularly stress—has a major impact on how efficiently these systems function.

When stress hits, it triggers a cascade of reactions in the nervous system that can interfere with your body’s detox processes. This can lead to a build-up of toxins and waste that your body struggles to clear, setting the stage for chronic health issues.

Depression is more than sadness—it's a systemic condition affecting mind and body. While the serotonin deficiency theory led to the widespread use of SSRIs like Prozac, research now suggests depression is far more complex. Only about 10% of SSRI efficacy is biological, with a significant placebo effect. Worse, long-term SSRI use may increase depression risk and double suicide rates.

Genetic studies have identified over 700 variants linked to depression, yet serotonin-related genes account for just a fraction. Key genes like BDNF (affecting brain plasticity) and COMT (impacting dopamine metabolism) play a greater role. Additionally, depression isn't solely a brain disorder—chronic stress, inflammation, and metabolic dysfunction all contribute.

Polyvagal Theory and heart rate variability research suggest depression may be a biological energy crisis, where prolonged stress leads to mitochondrial dysfunction. When the body remains in fight-or-flight mode too long, the inflammatory reflex disrupts cellular function, leading to depressive symptoms.

This shift in understanding calls for new treatment approaches. Rather than focusing only on serotonin, addressing inflammation, nervous system regulation, and mitochondrial health may provide more effective long-term solutions.

Far from being mysterious, there is a very clear link between autoimmune disease and mental health: the autonomic nervous system. The state of your autonomic nervous system reflects both the state of your mental heath and how your immune system is functioning.